Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors
Kim, D. R; Orr, M. J.; Kwong, A. J.; Deibler, K. K.; Munshi, H. H.; Bridges, C. S; Chen, T. […]
Category: Translational Chemistry
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
Liu, Y.; Betori, R. C.; Pagacz, J.; Frost, G. B.; Efimova, E. V.; Wu, D.; Wolfgeher, D. J.; Bryan, T. […]
Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain
McCollum, M. M.; Larmore, M.; Ishihara, S.; Ng, L. C. T.; Kimura, L. F.; Guadarrama, E.; Ta, M. C.; Vien, […]
Discovery of Highly Potent Serotonin 5-HT2 Receptor Agonists Inspired by Heteroyohimbine Natural Products
Orr, M. J.; Cao, A. B.; Wang, C. T.; Gaisin, A.; Csakai, A.; Friswold, A. P.; Meltzer, H. Y.; McCorvy, […]
Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma
Kwong, A. J.; Pham, T. N. D.; Oelschlager, H. E.; Munshi, H. G.*; Scheidt, K. A.* ACS Med. Chem. Lett. 2021, […]
Non-classical MEKs: A review of MEK3-7 inhibitors
Kwong, A. J.; Scheidt, K. A.* Bioorg. Med. Chem. Lett. 2020, 30, 127203.