Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma

Translational Chemistry

Kim. D. R.; Orr, M. J.; Yu, X.; Munshi, H. H.; Wang, A.; Trudeau, C.; Kwong, A. J.; Cheng, S.-Y.; Scheidt, K. A.* ACS Med. Chem. Lett. 2024, 15, 258-264.

Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors

Translational Chemistry

Kim, D. R; Orr, M. J.; Kwong, A. J.; Deibler, K. K.; Munshi, H. H.; Bridges, C. S; Chen, T. J.; Zhang, X.; Lacorazza, H. D.; Scheidt, K. A.* ACS Med. Chem. Lett. 2023, 14, 606-613.

Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization

Translational Chemistry

Liu, Y.; Betori, R. C.; Pagacz, J.; Frost, G. B.; Efimova, E. V.; Wu, D.; Wolfgeher, D. J.; Bryan, T. M.; Cohen, S. B.; Scheidt, K. A.; Kron, S. J.* Cell Chem. Biol. 2022, 29, 1517-1531.      

Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain

Translational Chemistry

McCollum, M. M.; Larmore, M.; Ishihara, S.; Ng, L. C. T.; Kimura, L. F.; Guadarrama, E.; Ta, M. C.; Vien, T. N.; Frost, G. B.; Scheidt, K. A.; Miller, R. E.; DeCaen, P. G.*  Cell Rep. 2022, 40, 111248.    

Discovery of Highly Potent Serotonin 5-HT2 Receptor Agonists Inspired by Heteroyohimbine Natural Products

Translational Chemistry

Orr, M. J.; Cao, A. B.; Wang, C. T.; Gaisin, A.; Csakai, A.; Friswold, A. P.; Meltzer, H. Y.; McCorvy, J. D.*; Scheidt, K. A.* ACS Med. Chem. Lett. 2022, 13, 648-657.

Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma

Translational Chemistry

Kwong, A. J.; Pham, T. N. D.; Oelschlager, H. E.; Munshi, H. G.*; Scheidt, K. A.* ACS Med. Chem. Lett. 2021, 12, 1559-1567.